Clone Number: BXP-34
Immunogen: Mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR
Concentration: 250 ug/ ml
Storage buffer: PBS with 1% BSA and 0.1% sodium azide
Additional info: BXP-34 Mab was selected after immunization with the mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR. BXP-34 reacts with an internal epitope of BCRP, a 70 kD transmembrane half-transporter which is involved in multidrug resistance. BXP-34 did not cross-react with the human MDR1, MRP1, MRP2, MRP5 gene products.
References: Doyle LA et al. Proc Nat Acad Sci 1998; 95: 15665-15670/Scheffer GL et al. Cancer Res 2000; 60: 2589-2593/van der Kolk DM et al. Blood; 99: 3763-3770