Mouse anti-CD109, clone EBS-CD-046 (Monoclonal)

Clone Number: EBS-CD-046

Immunogen: recombinant human CD109.

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: CD109 is a GPI-anchored member of the alpha-2-macroglobulin (A2M) and complement family of proteins. It is expressed on activated T-cells, platelets, hematopoietic stem cells, megakaryocyte precursors, vascular endothelial cells, basal and myoepithelial cells of secretory glands, and squamous cell carcinomas. A 170-180 kDa precursor is autocatalytically reduced to 150 kDa and 120 kDa forms. On keratinocytes CD109 binds TGF-beta and associates with TGFbeta RI and TGF-beta RII, resulting in inhibition of TGF-beta signalling. Polymorphisms of CD109 include the platelet-specific Gov antigen and the blood group ABH antigens. Alloantibodies directed against these antigens result in unsuccessful platelet transfusions, neonatal alloimmune thrombocytopenia, and post-transfusion purpura.

References: Emori M, et al, PLoS One 8(12): e84187 (2013)

• Artikelnummer: SANMON9970
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9970
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Monkey (Primate)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Flow Cytometry
• Isotyp: IgG2a-k
• Wirt: Mouse