Mouse anti-CD11a, clone 87-6F9 (Monoclonal)

Clone Number: 87-6F9

Immunogen: stimulated human leucocytes

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: 87-6F9 Reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells tend to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory response through binding to ICAM 1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many other T-cell functions and immune phenomena. When paired with CD18, it forms the integrin alphaLbeta2 adhesion. 87-6F9 Potently blocks LFA-1 dependent homotypic cell aggregation and was typed in the IVth International Leucocyte Typing Workshop

References: Knapp et al. (Eds.), Leukocyte Typing IV, 1989 : sections N1 (pp. 543.551)/Petruzzelli L et al. J Immunol 155(2): 854-866 (1995)/Edwards CP et al. J Biol Chem 273(44): 28937-44 (1998)

• Artikelnummer: SANMON1025
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON1025
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Western Blotting, Flow Cytometry, Functional Assay
• Isotyp: IgG2b
• Wirt: Mouse