Mouse anti-CD74, clone EBS-CD-041 (Monoclonal)

Clone Number: EBS-CD-041

Immunogen: B lymphoblastoid cell line HFB1.

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: The CD74 cluster, established during the IVth and Vth Leukocyte Typing Workshops, comprises four species of proteins (MW 41/35/33 kDa), all coded by a single gene, consisting of nine exons. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. In tissue sections anti-CD74 show a binding pattern very similar to that of anti-HLA-DR. It binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. EBS-CD-041 epitope is localized in the extracellular domain of CD74.

References: Epstein A.L. et al. J. Immunol. 133: 1028-1036 (1984)/Marder, R.J. et al. Lab. Invest. 52: 497-504 (1985)/Lazova R. et al. Cancer 79: 2115-2124 (1997).

• Artikelnummer: SANMON9879
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9879
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Western Blotting, Flow Cytometry
• Isotyp: IgG1-k
• Wirt: Mouse