Mouse anti-Csk, clone CSK-04 (Monoclonal)

Clone Number: CSK-04

Immunogen: Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.

Concentration: n/a

Storage buffer: Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Additional info: C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase which resembles Src-family kinases, but unlike them lacks the conserved autophosphorylation site, the regulatory C-terminal tyrosine as well as myristylation and palmitylation. Csk negatively regulates Src-family kinases by phosphorylation of their C-terminal regulatory tyrosine. Disruption of the csk gene causes constitutive activation of Src-family kinases, and overexpression of Csk usually counteracts their signaling. The Csk-mediated regulation of those Src-family kinases that are localized in lipid rafts is enabled by a ubiquitously expressed transmembrane adaptor PAG (also known as Cbp, Csk-binding protein), which recruits Csk.

• Artikelnummer: SANMON3088
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON3088
• Green Labware: Nein
• Verpackungseinheit: 0,1 ml
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, Western Blotting, Immunocytochemistry
• Isotyp: IgG1
• Wirt: Mouse