Mouse anti-Cytokeratin 8, clone 35betaH11

Clone Number: 35betaH11

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: n/a

Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide

Additional info: Cytokeratin 8, a member of the Type II family of cytokeratins, is typically expressed in simple epithelium. The dimerization of cytokeratin 8 with cytokeratin 18 (labeled by 35betaH11) in the cytoplasm of simple epithelial cells allows for the formation of an intermediate filament cytoskeletal framework. This structure plays a role in the maintenance of cellular structural integrity and also functions in promoting signal transduction and cellular differentiation processes. Additionally, the presence of cytokeratin 8 has been detected in neoplastic epithelia, including glandular epithelium that can be found in prostate carcinoma. Positive immunoreactivity with anti-cytokeratin 8 is a useful indicator for the identification of normal and neoplastic epithelial tissues.

References: Battifora, H. Am J Surg Pathol 1988;12:24/Gown, AM, et al. Am J Clin Pathol 1985;84:413/Ljung G, et al. Prostate. 1997; 31:91-7

• Artikelnummer: SANMON-RTU1075
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON-RTU1075
• Green Labware: Nein
• Verpackungseinheit: 7 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgM
• Wirt: Mouse