Mouse anti-Drebrin Purified, clone DBN-N-03 (Monoclonal)

Clone Number: DBN-N-03

Immunogen: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Additional info: Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.SpecificityThe mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.Application detailsWestern blotting: Positive control: REH, Nalm-6, HEK293 cells.
Flow cytometry: Recommended dilution: 1-4 µg/ml. Intracellular staining.

• Artikelnummer: SANMON23039
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23039
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, Flow Cytometry
• Isotyp: IgG2b
• Wirt: Mouse
• Konjugat: Unconjugated