English
Mouse anti Estrogen Receptor alpha/ERα/ERS1
Mouse anti Estrogen Receptor alpha/ERα/ERS1, IgG1, Clone: AER304
Artikelnummer
NORMUB2054P
Verpackungseinheit
0,5ml
Hersteller
Nordic-MUbio
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Clone: AER304
Background: Estrogen receptor (ER) is a hormone binding molecule, which belongs to the nuclear hormone family of intracellular receptors. Estrogen receptors exist as alpha and beta forms encoded by separate genes ESR1 and ESR2. ERα and ERβ share a high degree of sequence homology and are activated by the hormone 17β-estradiol and related compounds, including phytoestrogens and xenoestrogens. Both ERα and ERβ function as transcription factors which mediate many of the biological effects of estradiol at the level of gene regulation. Both receptors and are involved in the normal development and function of numerous tissues. Studies also suggest that ER’s may be involved in a range of pathological conditions including cancers, neurodegenerative diseases and cardiovascular disease.
Source: AER304 is a mouse monoclonal IgG1 antibody derived by fusion of Sp2/0-Ag14 mouse myeloma cells with splenocytes from a BALB/c mouse, immunized with estrogen receptor protein purified from calf uterus.
Specificity: The antibody AER304 is directed against estrogen receptor alpha (ERα) and recognises amino acids residues 120 – 170, an epitope located in the B domain of ERα.
Formulation: Each vial contains 500 µl 0.2 mg/ml purified monoclonal antibody in phosphated buffered saline (PBS) containing 50% glycerol + 0.2% bovine serum albumin (BSA) + 0.02% sodium azide.
References: 1. Abbondanza C. et al. (1993) Characterization and epitope mapping of a new panel of monoclonal antibodies to estradiol receptor. Steroids. 58: 4-12.
UniProt: UniProt: P03372 (Human)
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Background: Estrogen receptor (ER) is a hormone binding molecule, which belongs to the nuclear hormone family of intracellular receptors. Estrogen receptors exist as alpha and beta forms encoded by separate genes ESR1 and ESR2. ERα and ERβ share a high degree of sequence homology and are activated by the hormone 17β-estradiol and related compounds, including phytoestrogens and xenoestrogens. Both ERα and ERβ function as transcription factors which mediate many of the biological effects of estradiol at the level of gene regulation. Both receptors and are involved in the normal development and function of numerous tissues. Studies also suggest that ER’s may be involved in a range of pathological conditions including cancers, neurodegenerative diseases and cardiovascular disease.
Source: AER304 is a mouse monoclonal IgG1 antibody derived by fusion of Sp2/0-Ag14 mouse myeloma cells with splenocytes from a BALB/c mouse, immunized with estrogen receptor protein purified from calf uterus.
Specificity: The antibody AER304 is directed against estrogen receptor alpha (ERα) and recognises amino acids residues 120 – 170, an epitope located in the B domain of ERα.
Formulation: Each vial contains 500 µl 0.2 mg/ml purified monoclonal antibody in phosphated buffered saline (PBS) containing 50% glycerol + 0.2% bovine serum albumin (BSA) + 0.02% sodium azide.
References: 1. Abbondanza C. et al. (1993) Characterization and epitope mapping of a new panel of monoclonal antibodies to estradiol receptor. Steroids. 58: 4-12.
UniProt: UniProt: P03372 (Human)
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
| Artikelnummer | NORMUB2054P |
|---|---|
| Hersteller | Nordic-MUbio |
| Hersteller Artikelnummer | MUB2054P |
| Verpackungseinheit | 0,5ml |
| Mengeneinheit | STK |
| Reaktivität | Human |
| Klonalität | Monoclonal |
| Methode | Immunoprecipitation, Western Blotting, Immunocytochemistry |
| Isotyp | IgG1 |
| Wirt | Mouse |
| Konjugat | Unconjugated |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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