Clone Number: A9E4
Immunogen: BSA-conjugated peptide corresponding to amino acids 1-29 of human GnRH receptor extracellular domain
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: A9E4 reacts with GnRH receptors in the anterior pituitary. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinising hormone (LH) as well as follicle-stimulating hormone (FSH). The receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular, and intracellular loops, characteristic of G-protein coupled receptors. Some cancers like ovarian and breast cancers sometimes carry GnRH receptors
References: Karande, AA, et al, Molec. Cell. Endocrinol. 114: 51-56 (1995)