Mouse anti-Granzyme B Purified, clone CLB-GB11 (Monoclonal)

Clone Number: CLB-GB11

Immunogen: Human NK cell line YT-INDY-derived granzyme B

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Additional info: Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.SpecificityThe mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.Application detailsFlow cytometry: Recommended dilution: 1-4 μg/ml. Intracellular staining.

• Artikelnummer: SANMON23046
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23046
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Primate
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse
• Konjugat: Unconjugated