Mouse anti-GRAP2 Purified, clone UW40 (Monoclonal)

Clone Number: UW40

Immunogen: GST-fusion human GRAP2/GADS protein

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.SpecificityThe mouse monoclonal antibody 2H3 recognizes D1 domain of human histone deacetylase 6 (HDAC6; intracellular antigen), amino acids 281-291. Crossreactivity with other species was not tested.Application detailsFlow cytometry: Recommended dilution: 2-6 μg/ml. Intracellular staining.

• Artikelnummer: SANMON23047
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23047
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotyp: IgG2a
• Wirt: Mouse
• Konjugat: Unconjugated