Clone Number: EP-4
Immunogen: Lymphocytes from HLA-B27 individual
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: EP-4 recognizes the HLA-B27 cell surface antigen on human cells. HLA-B27 has been found to be highly associated (60%) with ankylosing spondylitis (Bekhterev's disease, MarieStrümpell disease or "bamboo spine"). While rheumatoid factor tests will be negative, testing for the presence of HLA-B27 in a patient can confirm the diagnosis of ankylosing spondylitis. Also postgonococcal arthritis and acute anterior uveitis are associated with HLA-B27.
References: Hansen JA et al. Hematol Oncol Clin North Am, 4(3): 507-515 (1990)/El-Shabrawi, Y. et al. Ophthalmology 113: 695-700 (2006)./Kellner H, Clin Investig. 72(4): 321-8 (1994)