Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody (CR3/43)

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Phosphate Buffered Saline (PBS) with 0.09% Sodium Azide, BSA-Free

Shelf Life: 1 year from date of receipt

Protein ID: NP_061984.2

Uniprot ID: P01903

Background: In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ∼70% similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.

Immunogen: Cells from human tonsil

• Artikelnummer: BEYA500-034ACF
• Hersteller: Bethyl Laboratories
• Hersteller Artikelnummer: A500-034ACF
• Green Labware: Nein
• Verpackungseinheit: 100 µl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: Whole IgG
• Human Gene ID: 3122
• Wirt: Mouse