Mouse anti-Hu CD100 Purified, clone 133-1C6 (Monoclonal)

Clone Number: 133-1C6

Immunogen: PHA stimulated human PBL

Concentration: 1 mg/ml

Format: Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: CD100, also known as semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis, invasive growth, proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients.SpecificityThe mouse monoclonal antibody BB27 recognizes an extracellular epitope of CD101, a 140 kDa disulfide-bonded homodimeric protein expressed on activated T cells, and some other cell types, such as granulocytes and cells of the monocyte/macropgage lineage.Application detailsFlow cytometry: Recommended dilution: 1-4 μg/ml.

• Artikelnummer: SANMON23065
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23065
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, ELISA, Flow Cytometry
• Isotyp: IgM
• Wirt: Mouse
• Konjugat: Unconjugated