Mouse anti-Hu CD11c Purified, clone BU15 (Monoclonal)

Clone Number: BU15

Immunogen: Dendritic cells of synovial fluid

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.SpecificityThe mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.Application detailsFlow cytometry: Recommended dilution: 1-4 μg/ml.

• Artikelnummer: SANMON23079
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23079
• Green Labware: Nein
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Monkey (Primate)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Immunoprecipitation, Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse