Mouse anti-Hu CD367 Purified, clone 9E8 (Monoclonal)

Clone Number: 900000000

Immunogen: CD367 ectodomain fused with human Fc

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: CD367 is an approximately 20-28 kDa C-type lectin with immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic part. CD367 binds in calcium-dependent manner to mannose, fucose, and weakly also to N-acetylglucosamine. It is expressed on dendritic cells, macrophages, monocytes, B cells, and neutrophils. In rheumatoid arthitis patients CD367 is expressed also on CD4+ T cells. After ligand-mediated triggering, it is internalized by clathrin-dependent endocytosis and contributes to the antigen presentation to CD8+ T cells. It may also be involved in modulation of the antigen presenting cell response.SpecificityThe mouse monoclonal antibody 15E2 recognizes an extracellular epitope LWEDGSTFSSN of human CD369 (Dectin-1), a 33 kDa transmembrane glycoprotein expressed predominantly on dendritic cells.Application detailsFlow cytometry: Recommended dilution: 1-4 µg/ml

• Artikelnummer: SANMON23188
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23188
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Primate
• Klonalität: Monoclonal
• Methode: ELISA, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG1 kappa
• Wirt: Mouse
• Konjugat: Unconjugated