Mouse anti-Hu CD42b Purified, clone AK2 (Monoclonal)

Clone Number: AK2

Immunogen: Human platelets

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Specificity: The mouse monoclonal antibody A59 recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages. Application details: Flow cytometry: Recommended dilution: 1-4 μg/ml.

References: Vettore S et al. Haematologica 2008, 93(11): 1743-7 /Welsh JD et al. J Thromb Haemost 2012, 10(11):2344-53

• Artikelnummer: SANMON23001
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23001
• Green Labware: Nein
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, Western Blotting, ELISA, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG1
• Wirt: Mouse