Clone Number: 4H9
Immunogen: Corticotrophin Releasing Factor conjugated to Bovine Serum Albumin
Concentration: IgG 1 mg/ml
Format: Purified
Storage buffer: PBS with <0.1% sodium azide
Additional info: Mouse anti Human Corticotrophin Releasing Factor antibody, clone 4H9 recognizes human corticotrophin releasing factor (CRF), a hormone found mainly in the hypothalamus that regulates the release of corticotrophin from the pituitary gland. The unique lysine residue (Lys-36) is likely to be involved in the antigenic determinant as lysine modification by CA blocks binding completely. Human serum, containing CRF-binding protein, also inhibits the binding of this antibody to CRF.
References: Kravchenko IV & Furalev VA. Hybridoma 1994; 13: 59-64/DeBellis A et al. J Clin Endocrinol Metab 2012; 97: 3684-90