Mouse anti Human Proximal Nephrogenic Renal Antigen, cln PN-15 (66.4.C2)

Mouse anti Human Proximal Nephrogenic Renal Antigen, cln PN-15 (66.4.C2), Monoclonal, IgG2b, Clone: 66.4.C2

Clone: 66.4.C2.

Background: This antibody reacts with a glycoprotein of 200 kDa present in proximal renal tubules. The antigen is a carbohydrate in nature and retained in formalin fixed paraffin embedded tissues. Other normal tissues that display the antigen include breast, parathyroid glands and epididymis. Among renal carcinomas, 93% of primary and 84% of metastatic carcinomas are positive for this antigen. Relatively few other tumor types are positive: breast cancers, teratocarcinomas and parathyroid adenomas.

Purification Method: Protein A/G Chromatography.

Source: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with renal cortical tissue extract and mouse myeloma cells.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Yoshida, S.O. and Imam, A., 'Monoclonal antibody to a proximal nephrogenic renal antigen: immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas.' Cancer Res. 1989, 49, 1802-1809.
2. Piron, A., et al. 'In vitro demonstration of a mitogenic activity in renal tissue extracts during regenerative hyperplasia.' Am. J. Physiol. 1998, 274, F348-F357.

UniProt: Q16790.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1234M
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1234M
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Immunohistochemistry (paraffin)
• Isotyp: IgG2b
• Wirt: Mouse