Mouse anti-JAM-C, clone CRAM-18 F26

Clone Number: CRAM-18 F26

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: The monoclonal antibody CRAM-18 F26 recognizes junctional adhesion molecule-C (JAM-C) also known as JAM-2, a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-18 F26 also reacts with human JAM-C. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.

References: Aurrand-Lions; M et al. J Biol Chem 2001; 276: 2733 /Aurrand-Lions, M et al Blood 2001, 98: 3699 /Johnson-Leger; C et al. Blood 2002; 100: 2479

• Artikelnummer: SANMON4024
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON4024
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Immunoprecipitation, ELISA, Flow Cytometry, Functional Assay
• Isotyp: IgG2a
• Wirt: Mouse