Mouse anti-Major Vault Protein, clone 1011 (Monoclonal)

Clone Number: 1011

Immunogen: affinity purified nuclear extract proteins

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: 1011 Is specific for the major vault protein, a 104-kDa highly conserved protein interacting with estrogen receptor. It is one of a series of four mAbs which recognize different epitopes of the protein. Major vault proteins have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

References: Abbondanza, C. et al, J. Cell Biol. 141, 1301-1310 (1998)/Den Boer, M.L. et al. Blood 91, 2092-2098 (1998)

• Artikelnummer: SANMON9043
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9043
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Immunoprecipitation, Western Blotting
• Isotyp: IgG1
• Wirt: Mouse