Mouse anti-MRP2 (ABCC2), clone M2III-6 (Monoclonal)

Clone Number: M2III-6

Immunogen: 202-amino acid COOH terminal end of the protein.

Concentration: 100 ug/ml

Format: Protein G purified

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: M2III-6 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2III-6 was raised against a bacterial fusion protein of cMOAB/MRP2, containing the 202-amino acid COOH terminal end of the protein. M2III-6 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.

References: Paulusma et al. Science 1996; 271: 1126-1128/Kool et al. Cancer Res 1997; 57: 3537-3547/Scheffer et al. Cancer Res 2000; 60: 5269-5277

• Artikelnummer: SANMON9027C
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9027C
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Western Blotting, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG2a
• Wirt: Mouse