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Mouse anti Ovarian Cancer associated antigen
Mouse anti Ovarian Cancer associated antigen, Monoclonal, IgG1, Clone: OVTL16
Artikelnummer
NORMUB1400P
Verpackungseinheit
100 µg
Hersteller
Nordic-MUbio
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Clone: OVTL16
Background: A central concept in tumor immunology is that malignancies bear tumor associated antigens, which are not or to a much lesser degree found in normal tissues. These antigens can be used as distinctive markers in diagnosis and therapy. As a consequence, monoclonal antibodies to such antigens may represent useful tools for histopathology, immunoscintigraphy and for immunotherapy.
Source: OVTL16 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with cyst fluid, obtained from a patient with a poorly differentiated Human ovarian carcinoma.
Specificity: OVTL16 recognizes a conformational epitope on ovarian carcinoma membrane antigen OA3 which is present in ovarian carcinomas and in cyst fluids obtained from these carcinomas, as well as in oviductal carcinomas and some endometrial carcinomas
References: Boerman, O., Makkink, K., Massuger, L., Thomas, C., Kenemans, P., Hanselaar, T., and Poels, L. (1989). Monoclonal antibodies anti ovarian carcinoma-associated antigens, raised by immunization with cyst fluids, Anticancer Res 9, 551-8 Boerman, O., Massuger, L., Makkink, K., Thomas, C., Kenemans, P., and Poels, L. (1990). Comparative in vitro binding characteristics and biodistribution in tumor-bearing athymic mice of anti-ovarian carcinoma monoclonal antibodies. Anticancer Res 10, 1289-1295. van Niekerk, C. C., Ramaekers, F. C., Hanselaar, A. G., Aldeweireldt, J., and Poels, L. G. (1993). Changes in expression of differentiation markers between normal ovarian cells and derived tumors, Am J Pathol 142, 157-77. Slobbe, R., Poels, L., ten Dam, G., Boerman, O., Nieland, L., Leunissen, J., Ramaekers, F., and van Eys, G. (1994). Analysis of idiotope structure of ovarian cancer antibodies: recognition of the same epitope by two monoclonal antibodies differing mainly in their heavy chain variable sequences, Clin Exp Immunol 98, 95-103. van Niekerk, C. C., Vooijs, P., Casparie-van Velsen, I. J., and Poels, L. G. (1997). Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev 21, 247-257.
UniProt: P15941
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Background: A central concept in tumor immunology is that malignancies bear tumor associated antigens, which are not or to a much lesser degree found in normal tissues. These antigens can be used as distinctive markers in diagnosis and therapy. As a consequence, monoclonal antibodies to such antigens may represent useful tools for histopathology, immunoscintigraphy and for immunotherapy.
Source: OVTL16 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with cyst fluid, obtained from a patient with a poorly differentiated Human ovarian carcinoma.
Specificity: OVTL16 recognizes a conformational epitope on ovarian carcinoma membrane antigen OA3 which is present in ovarian carcinomas and in cyst fluids obtained from these carcinomas, as well as in oviductal carcinomas and some endometrial carcinomas
References: Boerman, O., Makkink, K., Massuger, L., Thomas, C., Kenemans, P., Hanselaar, T., and Poels, L. (1989). Monoclonal antibodies anti ovarian carcinoma-associated antigens, raised by immunization with cyst fluids, Anticancer Res 9, 551-8 Boerman, O., Massuger, L., Makkink, K., Thomas, C., Kenemans, P., and Poels, L. (1990). Comparative in vitro binding characteristics and biodistribution in tumor-bearing athymic mice of anti-ovarian carcinoma monoclonal antibodies. Anticancer Res 10, 1289-1295. van Niekerk, C. C., Ramaekers, F. C., Hanselaar, A. G., Aldeweireldt, J., and Poels, L. G. (1993). Changes in expression of differentiation markers between normal ovarian cells and derived tumors, Am J Pathol 142, 157-77. Slobbe, R., Poels, L., ten Dam, G., Boerman, O., Nieland, L., Leunissen, J., Ramaekers, F., and van Eys, G. (1994). Analysis of idiotope structure of ovarian cancer antibodies: recognition of the same epitope by two monoclonal antibodies differing mainly in their heavy chain variable sequences, Clin Exp Immunol 98, 95-103. van Niekerk, C. C., Vooijs, P., Casparie-van Velsen, I. J., and Poels, L. G. (1997). Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev 21, 247-257.
UniProt: P15941
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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