Mouse anti-p53, clone Pab122 (Monoclonal)

Clone Number: Pab122

Immunogen: SV40 infected 3T3 cells, 3T3/SV40 clone 4 (B4)

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: PAb 122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb 122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

References: Gurney et al, J. Virol. 34(3): 752-763, (1980)/Tack et al, J. Virol. 58(2): 635-45, (1986)

• Artikelnummer: SANMON7049
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON7049
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Monkey (Primate), Dog (Canine)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Flow Cytometry
• Isotyp: IgG2b
• Wirt: Mouse