Mouse anti-p57 Protein (Kip2), clone 25B2 (monoclonal)

Clone Number: 25B2

Immunogen: Prokaryotic recombinant antigen corresponding to a 116 amino acid region of the N-terminus of the p57 protein.

Concentration: Greater than or equal to 19 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: Cyclin-dependent kinases are positive regulators of cell proliferation. p57 protein acts as a tumor suppressor to counter this. It is closely related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms’ tumors and tumors associated with the Beckwith-Wiedermann syndrome. There is increasing interest in p57 as a marker in gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviors. 

References: Kanthan R et al.World Journal of Surgical Oncology 2010; 8:10/Sharifi N et al.Journal of the Turkish-German Gynecological Association 2009;10:39-42/Maggiori MS and Peres LC. European Journal of Obstetrics and Gynecology and Reproductive Biology 2007; 135: 170-176

• Artikelnummer: SANMONX11160
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MONX11160
• Green Labware: Nein
• Verpackungseinheit: 1ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Wirt: Mouse