Mouse anti-P63, clone TP63/11 (Monoclonal)

Clone Number: TP63/11

Immunogen: Recombinant human p63 protein

Concentration: n/a

Format: Concentrate

Storage buffer: Bioreactor Concentrate with 0.05% Azide

Additional info: p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratin’s and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80%. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue Breast, Prostate, Prostate carcinoma or lung or bladder squamous cell carcinoma

References: Yang A, et al. Mol Cell 1998;2:305-16/Signoretti S, et al Am J Pathol 2000;157:1769-75/Yang A, et al. Nature 1999;398:714-18

• Artikelnummer: SANMON10227
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON10227
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG2a
• Wirt: Mouse