Mouse anti-Placental Alkaline Phosphatase (PLAP), clone H7E8 (H7) (Monoclonal)

Clone Number: H7E8

Immunogen: PLAP, purified from FS phenotype human placenta

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: PLAP is a tissue specific, throphoblast-derived, 58 kDa, glycosyl-phosphatidylinositol (GPI)- anchored, dimeric, Zn2+ metallated glycoprotein, only found in humans, orangutans and chimpanzees, that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APs in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non tissue specific AP is found in kidney, liver and bone. H7E8 binds equally well to all common allelic variants (S,F, FS and I) of PLAP as to AP from normal human testis, while antibody F5C2 reacts with some samples of normal human testis only.

References: Millan J.L. et al, Eur. J. Biochem. 136: 1-7 (1983)

• Artikelnummer: SANMON9839
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9839
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Immunoprecipitation, Western Blotting, ELISA, Flow Cytometry
• Isotyp: IgG2a-k
• Wirt: Mouse