Mouse anti-Polo-Like Kinase 1 (PLK-1), clone MJS1 (monoclonal)

Clone Number: MJS1

Immunogen: 107 amino acids from central region of human PLK-1 protein.

Concentration: Greater than or equal to 320 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: Polo-Like Kinase-1 (PLK1) also known as Serine/Threonine Protein Kinase 13 is a 66 kDa kinase. The activity of PLK-1 is crucial for mitosis and maintenance of genome stability. PLK-1 localizes to centrosomes and kinetochores where it plays a key role in late prophase and prometaphase. PLK-1 is overexpressed in many types of cancers and mediates estrogen receptor-mediated gene transcription in breast cancer cells. Overexpression of PLK-1 is associated with tumor development, with elevated levels of expression reported in non-small cell lung cancers, head and neck, gastric, breast, ovarian, colon and several other cancer types.

• Artikelnummer: SANMONX11161
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MONX11161
• Verpackungseinheit: 1ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1 kappa
• Wirt: Mouse
• Konjugat: Unconjugated