Mouse anti-Thyroid Transcription Factor-1, clone SPT24 (monoclonal)

Clone Number: SPT24

Immunogen: Prokaryotic recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of the TTF-1 molecule.

Concentration: Greater than or equal to 108 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: Thyroid Transcription Factor-1 (TTF-1) is a member of the homeodomain transcription factor family and plays a role in regulating genes expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins. Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sharing 98% homology with the equivalent rat and mouse proteins. TTF-1 functions by binding to specific recognition sites in a manner that may be regulated by both the redox and phosphorylation status of the protein. In addition to its role as a tissue-specific transcriptional activator in adult organs, TTF-1 may also function in organogenesis. Gene targeting studies have shown TTF-1 to be essential for the proper development of the thyroid and lungs and abnormal expression may underline a number of congenital abnormalities.

References: Unal B et al. Turkish Journal of Pathology. 2014; 30(3): 201-205/Klingen TA et al. Diagnostic Pathology. 2013; 8: 80-86/Berghmans T et al. Lung Cancer. 2006; 52(2): 219-224

• Artikelnummer: SANMONX10584
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MONX10584
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Wirt: Mouse