Mouse anti-UACA, clone AE-5 (Monoclonal)

Clone Number: AE-5

Immunogen: nuclei of myeloid leukemia biopsy cells

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, a mRNA differentially expressed in F9 embryonal carcinoma cells, and that is up-regulated during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1- pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

References: Yamada, K., et al. Biochem. Biophys. Res. Commun. 280: 1169-1176 (2001)/Ohkura, T., et al. Biochem. Biophys. Res. Commun. 321: 432-440 (2004)

• Artikelnummer: SANMON9843
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9843
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Western Blotting, Flow Cytometry
• Isotyp: IgG1-k
• Wirt: Mouse
• Konjugat: Unconjugated