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Mouse anti-UACA, clone AE-5 (Monoclonal)
Mouse anti-UACA, clone AE-5 (Monoclonal)
Artikelnummer
SANMON9843
Verpackungseinheit
100 µg
Hersteller
Sanbio / Monosan
Verfügbarkeit:
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Clone Number: AE-5
Immunogen: nuclei of myeloid leukemia biopsy cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, a mRNA differentially expressed in F9 embryonal carcinoma cells, and that is up-regulated during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1- pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
References: Yamada, K., et al. Biochem. Biophys. Res. Commun. 280: 1169-1176 (2001)/Ohkura, T., et al. Biochem. Biophys. Res. Commun. 321: 432-440 (2004)
Immunogen: nuclei of myeloid leukemia biopsy cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, a mRNA differentially expressed in F9 embryonal carcinoma cells, and that is up-regulated during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1- pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
References: Yamada, K., et al. Biochem. Biophys. Res. Commun. 280: 1169-1176 (2001)/Ohkura, T., et al. Biochem. Biophys. Res. Commun. 321: 432-440 (2004)
| Artikelnummer | SANMON9843 |
|---|---|
| Hersteller | Sanbio / Monosan |
| Hersteller Artikelnummer | MON9843 |
| Green Labware | Nein |
| Verpackungseinheit | 100 µg |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine) |
| Klonalität | Monoclonal |
| Methode | Immunofluorescence, Immunohistochemistry (frozen), Western Blotting, Flow Cytometry |
| Isotyp | IgG1-k |
| Wirt | Mouse |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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