Mouse anti-Wilms' Tumor, clone WT49 (monoclonal)

Clone Number: WT49

Immunogen: A prokaryotic recombinant protein containing 1–181 amino acids of the N-terminal of the Wilms’ Tumor protein.

Concentration: Greater than or equal to 44 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.

References: Omeroglu A and Omeroglu G. Arch Pathol Lab Med. 2003; 127:e347-e348/Lee SB and Haber DA. Experimental Cell Research. 2001; 264:74-99

• Artikelnummer: SANMONX11064
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MONX11064
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Wirt: Mouse