NCT-02, CAS 790245-61-3

Formulation: A solid

Formal Name: 6,7-dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide

Purity: ≥98%

Formula Markup: C17H16N2O2S

Formula Weight: 312,4

Shelf life (days): 1460

CAS Number: 790245-61-3

Notes: NCT-02 is a degrader of cyclin K.{69568} It reduces the levels of cyclin K in patient-derived colorectal cancer (CRC) cells in a concentration-dependent manner. NCT-02 inhibits cancer cell proliferation in CRC tissue samples isolated from the colon (IC50s = 0.9-20.6 µM), as well as from hepatic, lung, and rectal metastases (IC50s = 0.5-11.8, 1, and 1.4-38.4 µM, respectively). It decreases the levels of Ataxia-telangiectasia mutated kinase (ATM) and RAD51 in patient-derived CRC tissues when used at concentrations 0.7 and 0.5 µM, respectively. NCT-02 (3 µM) reduces the number of spheroids formed and induces poly(ADP-ribose) polymerase (PARP) cleavage in patient-derived CRC spheroid cultures.

• Artikelnummer: CAY39568-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39568-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK