Product Type: Inhibitor
CAS No.: 4311-88-0
MolecularFormula: C13H13N3OS
Molecular Weight: 259,33
Source: Synthetic
Purity: >98%
Solubility: Soluble to 15 mM in ethanol, and to 30 mM in DMSO
Appearance: Light Yellow Solid
PubChem CID: 2828334
Scientific Background: Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).
References: 1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573.2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714.3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.