NFAT Luciferase Reporter CHO Cell Line (PKC/Ca2+ Signaling Pathway)

NFAT Luciferase Reporter CHO Cell Line (PKC/Ca2+ Signaling Pathway)
Artikelnummer
BPS78569
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience

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Applications: Monitor NFAT stimulationScreen for activators or inhibitors of the PKC/ Ca2+

Background: The protein kinase C (PKC)/ Ca2+ response pathway leads to activation of the transcription factor nuclear factor of activator T cells (NFAT). NFAT is regulated by Ca2+ and the Ca2+/calmodulin-dependent serine phosphatase calcineurin. NFAT proteins are phosphorylated and reside in the cytoplasm in resting cells; upon stimulation, they are dephosphorylated by calcineurin, translocate to the nucleus, and induce gene expression.

Description: The NFAT Luciferase Reporter CHO cell line (PKC/Ca2+ Signaling Pathway) contains a firefly luciferase gene under the control of NFAT response element stably integrated into CHO K1 cells. This cell line is validated for its response to phorbol 12-myristate 13-acetate (PMA) in the presence of ionomycin.

Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent

Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.

Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. 

Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)

Warnings: Avoid freeze/thaw cycles

Biosafety Level: BSL-1
Mehr Informationen
Artikelnummer BPS78569
Hersteller BPS Bioscience
Hersteller Artikelnummer 78569
Verpackungseinheit 2 vials
Mengeneinheit PAK
Wirt Hamster
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