Nilotinib, CAS 641571-10-0

BCR-ABL kinase inhibitor

Product Type: Inhibitor

CAS No.: 641571-10-0

MolecularFormula: C28H22F3N7O

Molecular Weight: 529,5

Source: Synthetic

Purity: ≥99%

Solubility: Soluble in DMSO (50 mg/ml), chloroform, DMF (~3 mg/ml), water(very poorly soluble, maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility), and ethanol(very poorly soluble)

Appearance: Crystalline powder

PubChem CID: 644241

Scientific Background: Nilotinib is a potent and selective Bcr/Abl tyrosine kinase inhibitor, as well as, an inhibitor of JAK2/STAT5, and MDM2 at the post-translational level. Nilotinib shows antiproliferative and antitumor effects in vivo.

References: 1. Gallipoli P., et al. (2014) Blood.2. Zhang H., Gu L., Liu T., Chiang K.Y., & Zhou M. (2014) PloS One. 9(6): e100960.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-463-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-463-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK