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Biological Activity: NLG919 potently blocks IDO-induced T cell suppression and restored Tcell responses with a reported ED50 of 80 nM in vitro. NLG919 reduced the concentration ofplasma and tissue kynurenine by ~50% after a single dose in mice. NLG919 enhanced theantitumor responses of naÍve, resting pmel-1 T-cells to vaccination with cognate hgp100 peptideplus CpG-1826 in IFA in mice bearing B16F10 tumors.
CAS Number: 1402836-58-1
Description: NLG919 is an orally available potent inhibitor of the indoleamine-2,3-dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediatesimmunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2,mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated forthe treatment of immunosuppression associated with cancer.
Format: White powder
Purity: ≥98%
Solubility: Soluble in DMSO at 15 mg/ml.
Storage Stability: Store as supplied at or below -20°C for up to 3 years. Stable in DMSO at-80°C for up to 6 months.
Biosafety Level: Not applicable (BSL-1)
References: 1. Driessens, G., et al., J. Immunother. Cancer. 2014; 2(Suppl 3):195.
2. Nayak, A., et al. J. Immunother. Cancer. 2014; 2(Suppl 3): 250.