Formulation: A solid
Formal Name: 8-hydroxy-6-methoxy-α-methyl-1-oxo-1H-2-benzopyran-3-acetic acid
Purity: ≥98%
Formula Markup: C13H12O6
Formula Weight: 264,2
Shelf life (days): 365
CAS Number: 181427-78-1
Notes: NM-3 is a synthetic isocoumarin and an inhibitor of angiogenesis.{66550} It inhibits S180 cell-induced angiogenesis in an implanted dorsal air sac in mice when administered at doses of 1, 3, and 10 mg/kg. NM-3 (10, 20, and 40 mg/kg) induces intratumoral apoptosis and reduces tumor microvascular density in an SGC-7901 gastric cancer mouse xenograft model.{66551} It decreases renal levels of VEGF, TGF-β1, and angiopoietin-2 (ANG-2) and renal fibrosis in the db/db transgenic mouse model of diabetes when administered at a dose of 100 mg/kg.{66552}