Scientific Background: A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.
References: 1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.