NSMCE2 Antibody - middle region : Biotin

Conjugation: Biotin

Description of Target: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NSMCE2

Key Reference: Zandi,P.P., (er) Am. J. Med. Genet. B Neuropsychiatr. Genet. (2007) In press

Molecular Weight: 28kDa

Peptide Sequence: Synthetic peptide located within the following region: KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE

Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.

Protein Name: E3 SUMO-protein ligase NSE2

Protein Size: 247

Purification: Affinity Purified

• Artikelnummer: AVIARP55690_P050-Btn
• Hersteller: Aviva Systems Biology
• Hersteller Artikelnummer: ARP55690_P050-Biotin
• Green Labware: Nein
• Verpackungseinheit: 100μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rabbit, Guinea Pig, Cow (Bovine), Horse (Equine)
• Klonalität: Polyclonal
• Methode: Western Blotting
• Human Gene ID: 286053
• Wirt: Rabbit