NVPBEZ235, CAS 915019-65-7

PI 3-kinase inhibitor

Product Type: Inhibitor

CAS No.: 915019-65-7

MolecularFormula: C30H23N5O

Molecular Weight: 469,5

Source: Synthetic

Purity: ≥97%

Solubility: Soluble in chloroform (1 mg/ml), 1-methyl-2-pyrrolidnone (2 mg/ml at 75 °C), DMSO (1.33 mg/ml), and DMF (10 mg/ml at 75 °C)

Appearance: Crystalline solid

PubChem CID: 11977753

Scientific Background: NVPBEZ235 is a specific PI 3-kinase (PI3K) tyrosine kinase inhibitor, which shows dual PI3K/mTOR inhibition. NVPBEZ235 has also been shown to inhibit ATR. It has demonstrated antiproliferative activity against tumor cell lines in animal models of cancer.

References: 1. Yasumizu Y., et al. (2014) J. Urology. 191(1): 227–234. 2. Shortt J., et al. (2013) Blood. 121(15): 2964–2974.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-465-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-465-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK