Solubility: May be dissolved in DMSO (25 mg/ml); or Ethanol (40 mg/ml)
Appearance: White to off-white powder
PubChem CID: 5283387
Scientific Background: Originally identified in the cerebrospinal fluid of sleep-deprived cats acting as an inducer of physiological sleep in animals (1). Displays agonist activity at cannabinoid CB1 receptors (Ki=8.13 µM) (2). Activates PPARΥ (3). Produces vasodilator effects in rats (4). Displays neuroprotective effects (5) and attenuates sepsis-induced intestinal injury (6).
References: 1.DL Boger et al. 1998 Curr. Pharm. Des. 4:303.2.JD Leggett et al. 2004 Br. J. Pharmacol. 141:253.3.M Dionisi et al. 2012 Lipids Health Dis. 11:51.4.C Hernandez-Diaz et al. 2020 Cannabis Cannabinoid Res. 5:42.5.M Maya-Lopez et al. 2020 Neurotox. Res. 37:126.6.Z Zou et al. Mediators Inflamm. 2019 2019:7854389 (eCollection 2019).
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.