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Background: Parthenolide is a sesquiterpene lactone and the active principle of feverfew (Chrysanthemum parthenium)
CAS Number: 20554-84-1
Description: Parthenolide specifically inhibits HDAC1 without affecting other class I/II HDACs.
Format: white to off-white crystalline solid.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Supplied As: (1aR,7aS,10aS,10bS,E)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Target: HDAC1
Biosafety Level: Not applicable (BSL-1)
References: 1. Gopal, Y.N.V., et al. 2007. Chemistry and Biology 14(7) 813-823.
2. Groenewegen, W.A., et al. 1990. J. Pharm. Pharmacol. 42: 553-557.
3. 2. Sumner, H., et al. 1992. Biochem. Pharmacol. 43: 2313-2320.
4. 3. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44 :737-740.
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