PAX-2, clone EP235, format concentrate

Clone Number: EP235

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: n/a

Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide

Additional info: PAX2 is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mllerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

References: Gnarra JR, et al. Cancer Res. 1995; 55:4092-8/Mazal PR, et al. Mod Pathol. 2005; 4:535-40/Chivukula M, et al. Int J Gynecol Pathol. 2009; 28:570-8

• Artikelnummer: SANPS352
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: PS352
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Wirt: Rabbit
• Konjugat: Unconjugated