PD-1 (Woodchuck) / NFAT - Reporter - Jurkat Recombinant Cell Line

PD-1 (Woodchuck) / NFAT - Reporter - Jurkat Recombinant Cell Line
Artikelnummer
BPS79456
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience

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Applications: Screen for activators or inhibitors of woodchuck PD-1 signaling in a cellular context Characterize the biological activity of woodchuck PD-1 and its interactions with ligands

Background: The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.

Description: Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of woodchuck (groundhog, Marmota monax) PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #HQ403652).

Host Cell Line: Jurkat

Mycoplasma Testing: The cell line has been screened using the PCR-based Venor™GeM Mycoplasma Detection kit (Sigma-Aldrich, #MP0025) to confirm the absence of Mycoplasma species.

Storage Stability: Immediately upon receipt, store vials in liquid nitrogen.

Supplied As: Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1
Mehr Informationen
Artikelnummer BPS79456
Hersteller BPS Bioscience
Hersteller Artikelnummer 79456
Verpackungseinheit 2 vials
Mengeneinheit PAK
Wirt Human
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