PD-L1 antibody (405-9A11)

Clone Name: 405-9A11

Light Chain: Kappa

Application Note: IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 33

Positive Control: Lung squamous carcinoma

Form: Liquid

Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.

Concentration:

Background: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot ID: Q9NZQ7

Antigen Species: Human

Immunogen: coupled to KLH, Last 19 amino acids at the carboxy-terminus of the human membrane-bound PDL1 polypeptide

Purification: Unpurified

Conjugation: Unconjugated

Full Name: CD274 molecule

• Artikelnummer: GTX03297-500
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX03297-500
• Green Labware: Nein
• Verpackungseinheit: 500 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Human Gene ID: 29126
• Wirt: Mouse