PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) (PDL1/2746), 1mg/mL

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Description: PD-L1 (also known as Programmed Death Ligand 1, CD274, and B7-H1) is one of two cell surface ligands that engage the negative regulatory T cell surface receptor PD-1. PD-L1 is a Type I transmembrane protein expressed on the plasma membrane of cells, such as activated macrophages and some tumor cells. Because binding of PD-1 by PD-L1 has a suppressive effect on the immune system, inhibition of the PD-1/PD-L1 pathway is a major strategy of immune-oncology therapies. PD-L1 is upregulated in certain cancers, and blocking PD-1 or PD-L1 can inhibit cancer growth.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: PDL1/2746

Entrez Gene ID: 29126

Immunogen: Recombinant fragment of human CD274 protein (around aa 39-191) (exact sequence is proprietary)

Verified AB Applications: Flow (surface) (verified)/IF (verified)/IHC (FFPE) (verified)/WB (verified)

Z-Antibody Applications: Flow, surface (verified)/IF (verified)/IHC, FFPE (verified)/WB (verified)

• Artikelnummer: BTMBNUM2746-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM2746-50
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Flow Cytometry, Immunohistochemistry
• Isotyp: IgG2b kappa
• Wirt: Mouse
• Konjugat: Unconjugated