Product Description: PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt[1].
Formula: C24H20ClN5O
References: [1]Emeline Leproult, et al. Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55.
CAS Number: 404844-11-7
Molecular Weight: 429.90
Compound Purity: 98.0
Research Area: Cancer
Target: Bcr-Abl;c-Kit;PDGFR