Product Type: Inhibitor
CAS No.: 477-47-4
MolecularFormula: C22H22O8
Molecular Weight: 414,4
Source: Synthetic
Purity: ≥96% (HPLC)
Solubility: Soluble in DMSO (10 mg/ml, warm) or dimethyl formamide (25 mg/ml)
Appearance: White solid
PubChem CID: 72435
Scientific Background: Picropodophyllotoxin is an inhibitor of insulin-like growth factor 1 receptor (IGF1R). Specifically, it inhibits IGF1R autophosphorylation. It has also been seen to increases the fraction of cells in the G2/M phase, reduce pAKT and pERK1/2, and upregulates apoptosis. Picropodophyllotoxin exhibits antiproliferative effects in multiple cancer cell lines.
References: 1. Girnita A., et al. (2004) Cancer Res. 64(1): 236–242.2. Strömberg T., et al. (2006) Blood. 107(2): 669–678.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.