PMS2 antibody (A16-4)

Clone Name: A16-4

Light Chain: Kappa

Application Note: IHC-P: Prediluted. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 96

Positive Control: Colon carcinoma, tonsil

Form: Liquid

Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.

Concentration:

Background: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]

Uniprot ID: P54278

Antigen Species: Human

Immunogen: Recombinant human PMS2 (C-terminus)

Purification: Unpurified

Conjugation: Unconjugated

Full Name: PMS1 homolog 2, mismatch repair system component

• Artikelnummer: GTX03301-6
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX03301-6
• Green Labware: Nein
• Verpackungseinheit: 6 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Human Gene ID: 5395
• Wirt: Mouse