Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: Granzymes are serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes and in natural killer cells. Anti-Granzyme B has been useful in diagnosing Natural killer/T cell lymphoma, as well as anaplastic large cell lymphoma. High percentages of cytotoxic T cells have been shown to be an unfavorable prognostic indicator in Hodgkin’s disease.
References: Kummer JA, et al. Clin Exp Immunol. 1995; 100:164-72/Oudejans JJ, et al. Am J Pathol. 1996; 148:233-40/Oudejans JJ, et al. Blood. 1997; 89:1376-82